李立

擅長(zhǎng)： 醫(yī)學(xué)影像診斷和分子影像學(xué)研究

簡(jiǎn)介： 現(xiàn)任中山大學(xué)附屬腫瘤醫(yī)院影像與微創(chuàng)介入中心教授/主任醫(yī)師，博士生導(dǎo)師。華南腫瘤學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室(2004DA105074)課題組負(fù)責(zé)人。廣東省高等學(xué)校“千百十工程”第七批省級(jí)培養(yǎng)對(duì)象。 專業(yè)學(xué)會(huì)兼職： 中國(guó)生物物理學(xué)會(huì)分子影像學(xué)專業(yè)委員會(huì)第一屆委員 中國(guó)抗癌協(xié)會(huì)大腸癌專業(yè)委員會(huì)肝轉(zhuǎn)移學(xué)組第一屆委員 廣東省抗癌協(xié)會(huì)大腸癌專業(yè)委員會(huì)常務(wù)委員 廣東省放射學(xué)會(huì)心胸學(xué)組委員 臨床醫(yī)療與科學(xué)研究經(jīng)驗(yàn)： 李立教授長(zhǎng)期從事醫(yī)學(xué)影像診斷和分子影像學(xué)研究工作，在智能磁共振造影劑研制、新型納米探針研發(fā)、腫瘤分子分期、多模態(tài)分子成像理論與動(dòng)物模型研究取得了重要成果。發(fā)表通訊作者/第一作者SCI收錄論著24篇，其中，通訊作者(或共同通訊作者)論著發(fā)表在Scientific Reports, Biomaterials, Clinical Cancer Research, Nanoscale, Cancer, Contrast Media & Molecular Imaging等國(guó)際著名期刊。以第一發(fā)明人獲得新型釓納米造影劑、乳腺影像CAD系統(tǒng)、穩(wěn)定表達(dá)Tet-off Advanced鼻咽癌細(xì)胞模型發(fā)明專利3項(xiàng)，申報(bào)多模態(tài)分子成像探針發(fā)明專利1項(xiàng)。 科研基金： 1、國(guó)家自然科學(xué)基金面上項(xiàng)目，81271622、釓-納米金雙模態(tài)分子成像探針及其成像相互影響機(jī)制的研究、2013/01-2016/12、85萬(wàn)元、主持。 2、國(guó)家自然科學(xué)基金面上項(xiàng)目，81071207、鼻咽癌生物發(fā)光與磁共振多模態(tài)成像模型研究、2011/01-2013/12、35萬(wàn)元、主持。 3、廣州市科技支撐計(jì)劃項(xiàng)目，2010J-E151、東方女性適用的乳腺鉬靶攝影計(jì)算機(jī)輔助診斷系統(tǒng)、2011/01-2013/12、15萬(wàn)元、主持。 4、高校基本科研業(yè)務(wù)費(fèi)中山大學(xué)重大項(xiàng)目培育和新興交叉學(xué)科資助計(jì)劃項(xiàng)目、10ykjcll、腫瘤分子影像基礎(chǔ)研究、2010/07-2012/12、30萬(wàn)元、主持。 5、國(guó)家自然科學(xué)基金面上項(xiàng)目，30770629、含釓納米材料磁共振分子影像造影劑的研制、2008/01-2010/12、28萬(wàn)元、主持。 6、廣州市科技計(jì)劃項(xiàng)目，2006Z3-D2041、新型磁共振造影劑—釓摻雜復(fù)合納米材料的研制、2006/01-2008/12、30萬(wàn)元、主持。 近年來(lái)發(fā)表論著(*通訊作者)： 1. Cao CY, Shen YY, Wang JD, Li L*, Liang GL*. Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents. Sci Rep 2013,3,1024 doi:10.1038/srep01024 (2013). 2. Tian XM, Shao YZ, He HQ, Liu H, Shen YY, Huang WL*, Li L*. Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging. Nanoscale 2013, 5(8), 3322-3329 3. Shen Y, Shao Y, He H, Tan Y, Tian X, Xie F*, Li L*. Gadolinium(3+)-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo. Int J Nanomedicine 2013,8:119-127 4. Cai HM, Cui CY, Tian HY, Zhang M, Li L*. A novel approach to segment and classify regional lymph nodes on computed tomography images. Comput Math Method M 2012,2012:145926 doi:10.1155/2012/ 145926 5. Shao YZ, Tian XM, Hu WY, Zhang YY, Liu H, He HQ, Shen YY, Xie FK, Li L*. The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI. Biomaterials 2012,33(27):6438-6446 6. Feng YP, Liu QC, Zhu JF, Xie FK, Li L*. Efficiency of ferritin as an MRI reporter gene in NPC cells is enhanced by iron supplementation. J Biomed Biotechnol 2012,2012:434878 doi:10.1155/2012/434878 7. Pang YC#, Li L#, Hu WY, Peng YX, Liu LZ, Shao YZ*. Computerized segmentation and characterization of breast lesions in dynamic contrast-enhanced MR images using Fuzzy c-means clustering and snake algorithm. Comput Math Method M 2012,2012:634907 doi:10.1155/2012/634907 (2011 SCI IF 0.684) 8. Cui CY, Cai HM, Liu LZ, Li LR, Tian HY, Li L*. Quantitative analysis and prediction of regional lymph node Status in rectal cancer based on computed tomography imaging. Eur Radiol 2011,21(11):2318-2325 9. Shao YZ, Liu LZ, Song XQ, Cao RH, Liu H, Cui CY, Li X, Bie MJ, Li L*. A novel one-step synthesis of Gd3+ incorporated mesoporous SiO2 nanoparticles for use as an efficient MRI contrast agent. Contrast Media Mol Imaging 2011,6(2):110-118 10. Feng YP, Liu QC, Zhu JF, Xie FK, Li L*. Development and applications of a nasopharyngeal carcinoma Tet-Off cell line. Oncol Lett 2011, 3(2):525-530 11. Shao YZ, Liu LZ, MJ, Li CC, Wu YP, Xie XM, Li L*. Characterizing the clustered microcalcifications on mammograms to predict the pathological classification and grading: a mathematical modeling approach. J Digital Imaging 2011, 24(5):764-771 12. Liu LZ, Liang SB, Li L*, Mao YP, Tang LL, Tian L, Liao XB, Cui CY, Lin AH, Ma J*. Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. Cancer 2009,115(9):1995-2003 13. Cui CY, Liu LZ, Ma J, Liang SB, Tian L, Tang LL, Li L*. Trigeminal nerve palsy in nasopharyngeal carcinoma: Correlation between clinical findings and magnetic resonance imaging. Head Neck 2009,31(6):822-828 14. Li L, Liu LZ, Wu QL, Mo YX, Liu XW, Cui CY, Wan DS*. CT-guided core needle in diagnosis of pancreatic diseases with an automated biopsy gun. J Vasc Interv Radiol 2008,19(1):89-94 15. Ma J, Liu L, Tang L, Zong J, Lin A, Lu T, Cui N, Cui C, Li L*. Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: prognostic value and staging categories. Clin Cancer Res 2007,13(5):1445-1452 16. Liu LZ, Zhang GY, Xie CM, Liu XW, Cui CY, Li L*. Magnetic resonance imaging of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: patterns of spread. Int J Radiat Oncol Biol Phys 2006,66(3):721-730 17. Li L, Wu PH, Huang JL, Liu RY, Zeng YX, Huang WL*. Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma. Int J Cancer 2006,118(8):2064-2071